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Author contributions: M. Chronic exposure to drugs of abuse is linked to long-lasting alterations in the function of limbic system structures, including the nucleus accumbens NAc. Although cocaine acts via dopaminergic mechanisms within the NAc, less is known about whether phasic dopamine DA signaling in the NAc is altered in animals with cocaine self-administration experience or if these animals learn and interact normally with stimuli in their environment. Here, separate groups of rats self-administered either intravenous cocaine or water to a receptacle controls , followed by 30 d of enforced abstinence.